<International Circulation>：What is the difference of the RAS in different adipose tissue? For example， are there any differences between visceral adipose tissue and subcutaneous adipose tissue? 
 

    《国际循环》：第二个问题，您认为不同的脂肪组织中肾素-血管紧张素存在哪些差异？比如，在内脏的脂肪组织和皮下脂肪组织？

    Prof. Cassis:That is a great question. We have shown experimentally in mice that high fat feeding causes a site-specific increase in angiotensinogen expression in visceral adipose tissue. Therefore， even with the RAS there does seem to be some differential regulation. We do not know the mechanisms of that and what we will probably be doing in these models we are creating is taking it out uniformly and it will be difficult to then get at the regional variations and how they contribute to the cardiovascular status but it is site-specifically increased viscerally.

    Cassis教授：这个问题涉及很广。我们已经证实，至少在实验小鼠体内，高脂饮食可显著诱导内脏脂肪组织中angiten cinnagen的表达。似乎存在与肾素-血管紧张素系统不同的血压调节方式，但我们不知道这些机制。我想我们将在这些模型上研究各脂肪组织RAS的均一性，探明RAS组织特异性及其如何影响心血管状态很困难。